(3) IMMUNOGLOBULIN ABNORMALITIES

Immunoglobulin Abnormalities in Gaucher ’ s Disease

S ERUM GAMMA GLOBULIN ABNORMALITIES have rarely been reported in Gaucher’s disease. We recently observed a patient with Gaucher’s disease who showed bone marrow plasmacytosis and a homogeneous midgamma “spike” on serum electrophoresis. Less than a year earlier, a similar patient had been reported from this hospital by Tyson, et al.1 Search of the literature disclosed two additional patients wit...

Preparation and characterization of a novel nanobody against T-cell immunoglobulin and mucin-3 (TIM-3)

Objective(s): As T-cell immunoglobulin and mucin domain 3 (TIM-3) is an immune regulatory molecule; its blocking or stimulating could alter the pattern of immune response towards a desired condition. Based on the unique features of nanobodies, we aimed to construct an anti-TIM-3 nanobody as an appropriate tool for manipulating immune responses for future therapeutic purposes. Materials and Meth...

Immunoglobulin abnormalities in bronchoalveolar lavage specimens from amiodarone-treated subjects.

Cerebrospinal fluid immunoglobulin abnormalities in systemic lupus erythematosus.

Central nervous system (CNS) involvement is a common and important complication in systemic lupus erythematosus. The mechanisms for CNS involvement are poorly understood and reliable diagnostic procedures are lacking. Pairs of serum and cerebrospinal fluid (CSF) specimens from 17 patients with clinical and serological manifestations of systemic lupus erythematosus were analysed. All 11 patients...

Stimulation of Camel Polyclonal Antibody against Human T cell Immunoglobulin and Mucin 3

Background: T cell Immunoglobulin, Mucin (TIM)-3, is a type I transmembrane glycoprotein belonging to TIM family. This receptor expresses on T helper type 1 (Th1) cells that binds to galectin-9 (Gal9); inducing an inhibitory signal. As a result, apoptosis of Th1 cells occurs and cytotoxicity of CD8 T cells becomes evident in vitro. Therefore, this immunomodulatory molecule may ...